Pathophysiology of Hidradenitis Suppurativa: From Follicular Occlusion to Tunnels

This concise video explores the pathophysiology of Hidradenitis Suppurativa (HS), tracing the disease process from initial follicular occlusion to the formation of chronic tunnels. It describes the early histological changes, characteristic of initial HS lesions, and highlights how the rupture of affected follicles triggers a robust immune activation and cellular recruitment involving various immune cells like T-cells, B-cells, monocytes, and macrophages, leading to a vigorous inflammatory response. Crucially, it highlights the unique shift from this intense inflammatory phase to irreversible fibrotic remodeling, resulting in the formation of characteristic tunnels and fistulas.

• Outline HS lesion progression as a staged process, from follicular occlusion and rupture to subsequent immune activation.

• Describe the histological features and the specific immune cell involvement that drives the inflammatory response in HS.

• Explain the critical transition from inflammation to chronic fibrotic remodeling and tunneling, and its contribution to the irreversible nature of tissue damage in HS.

MAT-GLB-2601200 - 1.0 - 04/2026