IMMERSE · 8-12 min
Immunology of Hidradenitis Suppurativa (HS)
IMMERSE Program · March 25, 2026
Overview
This interactive module introduces the pathogenesis of hidradenitis suppurativa, describing how follicular rupture triggers immune activation and escalating inflammation. It explains how interacting innate and adaptive immune pathways drive painful lesions, chronic progression, and tissue damage, and highlights the clinical burden and unmet needs in HS.
Learning Objectives
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Summarize the early biological events in HS, including follicular occlusion, rupture, and initiation of immune activation
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Describe how both innate and adaptive immune pathways contribute to persistent inflammation, recurrent lesions, sinus tract formation, and scarring
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Recognize how chronic immune activity relates to the real-world clinical burden of HS, including diagnostic delay, treatment cycling, and need for surgical intervention
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Understand how increased knowledge of HS pathogenesis supports earlier recognition, personalised therapy, and multidisciplinary management
MAT-GLB-2507281-1.0-02/2026