Clinical Heterogeneity in Hidradenitis Suppurativa (HS)

This concise video addresses the clinical heterogeneity of Hidradenitis Suppurativa (HS), highlighting its nature as a diverse inflammatory disease. It explores the complex interplay of interacting risk factors, including genetic susceptibility, smoking, obesity, and alterations in the microbiome, that contribute to HS development and progression. It details the diverse lesion morphologies characteristic of HS, such as inflammatory nodules, abscesses, tunnels, and scars. Emphasizing a comprehensive clinical approach, it stresses the importance of a full skin examination that extends beyond typical intertriginous “hot spots” to identify HS manifestations in less common areas like the neck, groin, and popliteal fossa.

• Understand that HS is a heterogeneous inflammatory disease driven by a complex interaction of genetic, lifestyle, and environmental risk factors.

• Recognize the diverse clinical manifestations and lesion morphologies of HS, including inflammatory lesions, sinus tracts, and scarring.

• Apply the understanding of HS heterogeneity to perform thorough clinical assessments, including full skin examinations across all potential affected areas.

MAT-GLB-2601198 - 1.0 - 04/2026