Pathophysiology of Atopic Dermatitis: T-cell Activation and Inflammation

In this video, Dr. Pedro Mendes-Bastos explores the pathophysiology of atopic dermatitis (AD) and explains how underlying mechanisms such as antigen-presenting cell (APC) and T cell interactions drive the chronicity of AD.

• Describe how AD immunopathogenesis extends across T-cell subsets, involving complex interactions between antigen-presenting cells (APCs), helper T (Th) cells, memory T cells (Tmems), regulatory T cells (Tregs), and multiple cytokine pathways

• Explain how costimulatory pathways such as OX40/OX40L signaling can amplify and sustain immune responses and help account for disease chronicity and heterogeneity across patients

MAT-GLB-2601204 - 1.0 - 03/2026